
Nilotinib hydrochloride
CAS No. 923288-95-3
Nilotinib hydrochloride( —— )
Catalog No. M33809 CAS No. 923288-95-3
Nilotinib hydrochloride(AMN-107 HCl) is an orally available Bcr-Abl tyrosine kinase inhibitor with antitumor activity for modulation of neuroinflammation and cognitive deficits, and may be used in studies of chronic myelogenous leukemia.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
5MG | 38 | Get Quote |
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10MG | 54 | Get Quote |
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25MG | 86 | Get Quote |
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50MG | 127 | Get Quote |
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100MG | 188 | Get Quote |
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500MG | 534 | Get Quote |
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1G | Get Quote | Get Quote |
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Biological Information
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Product NameNilotinib hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionNilotinib hydrochloride(AMN-107 HCl) is an orally available Bcr-Abl tyrosine kinase inhibitor with antitumor activity for modulation of neuroinflammation and cognitive deficits, and may be used in studies of chronic myelogenous leukemia.
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DescriptionNilotinib (AMN107) hydrochloride is an orally active Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity and can be used in studies of chronic myelogenous leukaemia.
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In VitroNilotinib hydrochloride, selective Abl inhibitor, is designed to interact with the ATP-binding site of BCR-ABL with a higher affinity than imatinib while being significantly more potent compared with imatinib (IC50<30 nM), also maintains activity against most of the BCR-ABL point mutants that confer Imatinib resistance.Nilotinib hydrochloride demonstrates significant antitumor efficacy against GIST xenograft lines and imatinib-resistant GIST cell lines which parent cell lines GK1C and GK3C shows imatinib sensitivity with IC50 of 4.59±0.97 μM and 11.15±1.48 μM, respectively, imatinib-resistant cell lines GK1C-IR and GK3C-IR shows Imatinib resistance with IC50 values of 11.74±0.17 μM (P<0.001) and 41.37±1.07 μM (P<0.001), respectively.
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In VivoNilotinib hydrochloride (oral gavage, 40 mg/kg, daily, 4 weeks) shows equivalent or higher antitumor effects in BALB/cSLc-nu/nu mice with GIST xenograft.Nilotinib hydrochloride has a significant healing effect on the macroscopic and microscopic pathologic scores and ensures considerable mucosal healing in the indomethacin-induced enterocolitis rat model while decreases the PDGFR α and β levels and apoptotic scores in the colon.Animal Model:BALB/cSLc-nu/nu mice with GIST xenograft (GK1X, GK2X and GK3X) Dosage:40 mg/kg Administration:Oral gavage; daily; 4 weeks Result:Inhibited tumor growth by 69.6% in GK1X, 85.3% in GK2X and 47.5% in GK3X xenograft line.
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Synonyms——
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PathwayAutophagy
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TargetAutophagy
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RecptorAutophagy | Bcr-Abl
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Research Area——
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Indication——
Chemical Information
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CAS Number923288-95-3
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Formula Weight565.98
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Molecular FormulaC28H23ClF3N7O
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Purity>98% (HPLC)
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Solubility——
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SMILESCl.O=C(NC=1C=C(C=C(C1)C(F)(F)F)N2C=NC(=C2)C)C3=CC=C(C(=C3)NC=4N=CC=C(N4)C5=CN=CC=C5)C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Weisberg E, et al. Beneficial effects of combining nilotinib and imatinib in preclinical models of BCR-ABL+ leukemias. Blood. 2007 Mar 1;109(5):2112-20.?
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